PGDD08 Pharmacogenomics: new opportunities for drug discovery
During the five days of the course, we will teach several topics relevant to structure-based drug discovery. Such topics include structure determination and prediction (days 1 and 2), human variability and pharmacogenomics (day 3), docking of small molecules from an experimental and computational prespective (day 4) and quantitative structure-activity relationships (day 5). This course is addressed to students with some knowledge of structural biology as well as computational biology. However, the course aims to introducethe students to the teoretical background as well as some practical applications. Attendees will be trained in software for: protein structure determination from NMR; structure prediction by MODELLER; SNP analysis; docking of small molecules by DOCK; QSAR analysis and generation of ligand libraries.
Topics covered:
Protein Structure Determination
Protein Structure Prediction
SNP Variability and Disease
Docking of Small Molecules
QSAR. Quantitative structure-activity relationships
